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Les persones amb insuficiència renal que entren en programa d'hemodiàlisi tenen una funció inferior al 10% de la funció normal. Amb xifres superiors de funció, generalment no és necessària l'hemodiàlisi.Cal practicar l'hemodiàlisi de forma periòdica, en sessions d'unes quatre hores i generalment tres cops per setmana, tot i que la durada i la freqüència depenen de cada pacient i de cada circumstància.El fonament de l'hemodiàlisi és biofísic, en el sentit que la sang quan passa per un filtre, intercanvia substàncies amb el líquid que hi ha present a l'altra banda del filtre i que és mogut en circulació per una màquina. Per a l'intercanvi, la sang s'allibera de la urea, del potassi, del fòsfor, i de diferents substàncies que s'acumulen pel dèficit del funcionament renal. El pas de les substàncies a través de la membrana es fa en part espontàniament, per què hi ha diferents concentracions de les diferents substàncies i la tendència és a igualar-se, i també per mitjà de canvis en la pressió que exerceix la màquina d'hemodiàlisi.Possibles complicacions de l'hemodiàlisi, són la infecció del catèter o l'esgotament dels accessos vasculars en pacients que estan durant anys amb hemodiàlisi.Tot que l'hemodiàlisi pot durar anys, generalment és un pas intermedi entre la insuficiència renal i el trasplantament.
Kidney biopsy is an essential diagnostic procedure in the field of nephrology. Kidney disease has a noticeable effect on a patient's general health and can also be detected by the blood and urine tests taken. Imaging tests (renal ultrasound, CT scan and nuclear magnetic resonance imaging) provide information for diagnosing kidney disease, but the essential and indisputable test to be able to reach a diagnosis of kidney disease is a kidney biopsy.
This consists of extracting a very small sample of kidney tissue, just a millimetre or so in size, with a special needle. The needle is guided by ultrasound and under local anaesthetic with or without sedation, depending on the characteristics of the patient.
The sample obtained is processed by the Pathological Anatomy Department for observation using optical microscope, fluorescence microscope and electronic microscope techniques. This enables different parts of the kidney to be observed: the glomerulus, the tubule, and the blood vessels. Special liquids can also be used to reveal infections and toxicity produced by different medicines.
This is very useful both for diagnosing disease in the kidneys themselves, as well as a test to monitor a kidney transplant.
Although a kidney biopsy is not without complications worth mentioning, they occur rarely and can be resolved. Urine may contain blood, for example, although this generally stops by itself. Renal haematoma may also occur, which also does not require treatment. Accidental communication between an artery and a vein may also occur, which can be repaired via catheterization to close the anomalous communication.
Kidney biopsy is a common procedure in the Nephrology Department and complications occur in around 1-2% of cases, which are subsequently resolved. It is therefore considered a safe routine procedure.
Analytical testing provides a lot of information which enables the origin and severity of the kidney disease to be established. A kidney biopsy allows a microscopic study that is often essential. Genetic testing also provides very important information.
These tests serve to determine the origin of the kidney disease. There are many causes that may be genetic or acquired via a bacterial or viral infection, or resulting from a metabolic disease (diabetes) or an autoimmune disease such as lupus.
In addition to blood and urine tests, a kidney biopsy and/or a genetic analysis, imaging tests can also be useful.
A kidney biopsy may produce minimal bleeding that almost always stops by itself. If it doesn't, it can be controlled using an interventional radiology procedure, whereby the kidney is catheterised to close the area of bleeding. Genetic testing is increasingly used to decrease the need for a kidney biopsy. However, kidney biopsy continues to be the main diagnostic method for kidney disease.
The kidneys benefit from a healthy diet, from a relatively high intake of water and from avoiding tobacco. Regular bowel and bladder movements are also essential. Constipation and delaying urination are both damaging to kidney function. Plain water without anything dissolved in it is necessary for good kidney function, apart from liquids such as milk and broth and drinks such as tea and coffee. The amount of urine a healthy person produces varies depending on how much water they drink, the air temperature, whether they are at rest or doing exercise, etc. A healthy adult would normally required 1 to 2 litres per day. Kidney function does not necessarily improve if excessive water is consumed.
Exercise and a diet rich in fibre encourage healthy bowel and bladder movements and improve kidney function. In terms of related conditions, often diabetes, good metabolic control of the diabetes is essential to preserve good kidney function. Controlling arterial pressure, which often has an unknown cause, is also vital to maintain good kidney function.
Complex glomerular diseases (or glomerulonephritis) are one of the most common causes of end-stage renal disease. The main measure to combat chronic kidney disease is prevention, following dietary guidelines, and early treatment of diseases or situations that may lead to it. In addition, when it is already established and advanced, treatments should be administered that totally or partially replace the functions of the kidneys, a renal replacement therapy.
On the one hand, the function of the kidneys is to eliminate impurities from the body through the urine, and regulate the amount of liquid and chemical elements that we need, such as sodium, potassium, phosphorus or calcium.
On the other hand, the kidneys also help in regulating blood pressure by activating vitamin D, which is required to maintain healthy bones, and producing erythropoietin, which is required to produce red blood cells in the bone marrow.
When the kidneys do not work properly, the impurities we generate and the water that the kidneys cannot eliminate accumulates in the blood and the tissues, and this causes major disruptions to the patient’s general health, fluid retention and hypertension. They are also unable to properly get rid of some medications we take, which can accumulated in the body, increasing the risk of side effects.
As the kidneys are unable to help make vitamin D, or to retain phosphorous, the bones are weakened. The kidneys are also unable to produce erythropoietin and therefore anaemia appears.
The main types of renal replacement therapy are:
Where patients will not benefit from renal replacement therapy, conservative treatment will be carried out, aimed at controlling the different disorders and symptoms that appear during evolution of the illness.
The majority of cases of glomerulonephritis cannot be prevented, although a healthy lifestyle is advised, as promoted by the Spanish National Health System:
In addition, the application of dietary and pharmacological measures can help prevent or decrease the progression of the illness:
Maintain a balanced diet and limit:
A urinary tract infection is defined as the presence of invasive bacteria in the urinary system, together with signs of inflammation, such as high temperature and local pain.
Urinary tract infections may be located in the lower urinary tract (bladder and urethra), or the upper urinary system, affecting one or both kidneys. A kidney infection is also known as pyelonephritis.
Infections of the lower urinary tract are characterised by localised pain, which increases when urinating, and sometimes by cloudy or dark urine, usually without high temperatures.
Kidney infections (pyelonephritis) are characterised by high temperatures, acute local pain in the lower back, and pain or irritation when urinating.
Urinary tract infection is characterised by the presence of local pain (lower abdomen or lumbar region), which increases when urinating. The urine is often cloudy, or dark if it contains blood. There may be high fever, especially in the case of pyelonephritis (an infection of the upper urinary tract).
It can affect people at any age, from early childhood to old age. It is more frequent among women and there are factors that make people vulnerable to it (pregnancy for women and enlarged prostate for men) as well as urological anomalies (pre-existing malformation or presence of kidney stones).
Urinary infections are diagnosed by examining urine under the microscope (sediment) to see whether it contains white blood cells and/or bacteria, and by cultivating the bacteria in a microbiological culture to identify the strain and determine the most appropriate antibiotic for treatment (antibiotic susceptibility testing).
Urinary tract infections are usually treated with antibiotics. Treatment is oral in the case of lower-tract infection.
For upper-tract infections (pyelonephritis) it is usually intravenous, although in some cases outpatient oral treatment may be administered.
The standard tests are urine sediment and culture (urine culture with antibiotic susceptibility testing). An ultrasound scan may be indicated for examining the kidney and urinary tract and identifying obstructions or kidney stones that may have brought about the infection.
Ultrasounds are also used to assess the state of the kidneys. A general analysis may also be indicated to see how the urinary tract infection is affecting the rest of the body, and specifically the renal function.
Urinary tract infection can be prevented by frequent urination (every 2 to 3 hours) and, above all, by avoiding the habit of holding in urine, and by going to the toilet whenever the bladder feels full, without waiting too long.
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