Vall d'Hebron Talks by VHIR 'Peripheral Inflammatory Immune profile in Parkinson's disease'

Speaker: Dr. Pablo Mir. Movement Disorders Unit, Department of Neurology and Clinical Neurophysiology, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocío/University of Seville/CSIC/CIBERNED, Seville, Spain- Biomedical Research Network Center on Neurodegenerative Diseases (CIBERNED), Carlos III Health Institute, Madrid, Spain - Department of Medicine, Faculty of Medicine, University of Seville, Seville, Spain.

Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, with neuroinflammation playing a significant role in its etiology and progression. Both central and peripheral immune responses are involved, and evidence suggests a brain-periphery interaction in PD. Changes in leukocyte subpopulations have been observed in PD patients, making the neutrophil-to-lymphocyte ratio (NLR) a relevant marker of peripheral inflammation. Patients with PD have a higher NLR compared to healthy controls, indicating increased peripheral inflammation. This higher NLR suggests that the neutrophil-to-lymphocyte ratio is a useful non-invasive biomarker of systemic inflammation in PD. The peripheral immune response differs among patients based on their genetic background, with those having sporadic and GBA-associated PD showing a higher NLR in contrast to those with LRRK2-associated PD. Furthermore, this elevated peripheral inflammation is associated with dopaminergic neurodegeneration, underscoring the importance of understanding inflammatory processes in the context of PD for better diagnostic and therapeutic strategies.

Host: Dr. Ariadna Laguna. Main researcher Neurodegenerative Diseases (VHIR)

Register here to attend by Zoom: https://gencat.zoom.us/j/94801616000