Vall d'Hebron Talks by VHIR 'Dystonia: Clinical aspects and pathogenesis'

Speaker: Prof. Emmanuel Flamand-Roze is neurologist at Pitié-Salpêtrière Hospitala and Professor of Neurology at Sorbonne University in Paris.

Abstract: Dystonia continues to pose a significant challenge to clinicians, with diagnosis mainly based on the history and the description of motor signs. Non-motor manifestations are also part of the clinical spectrum. In parallel with the broad heterogeneity of clinical manifestations among different types of dystonia, the biological mechanisms also show extensive heterogeneity. 
In this lecture, we will describe recent updates to its definition and classification and how they may assist clinicians in improving recognition and timely diagnosis. We will also discuss progress in the understanding of its pathogenesis and how it may provide therapeutic perspectives: targeting shared mechanisms needs to be considered alongside more individualized approaches.

Host. Dr. Belén Pérez Dueñas. Head of group Therapeutics and Innovations in Neuropediatrics and other paediatric rare diseases. Vall d'Hebron Research Institute (VHIR).