Vall d'Hebron Talks by VHIR 'Understanding the activation mechanism of the NLRP3 inflammasome'

 Vall d'Hebron Talks by VHIR
  Sala d’actes de la planta baixa de l’Hospital General — See in map
03/05/2023
03/05/2023 -- From 12:00h to 13:00h
Organize :
Vall d'Hebron Institut de Recerca (VHIR)
Modality: Presencial i en línia
Share it:

Speaker: Dr. Pablo Pelegrín, Scientific Deputy Director & Principal Investigator, BioMedical Research Institute of Murcia - Department of Biochemistry and Molecular Biology B and Immunology-Faculty of Medicine-University of Murcia

The NLRP3 inflammasome is activated in response to a wide range of stimuli and drives diverse inflammatory diseases. The decrease of intracellular K+ concentration is a minimal upstream signal to most of the different NLRP3 activation models. Here we found that cellular K+ efflux induces a stable structural change in the inactive NLRP3 promoting an open conformation as a step preceding activation. This conformational change is facilitated by the presence of the specific NLRP3 FISNA domain and a unique flexible linker sequence between the PYD and FISNA domains. This linker is also important to facilitate the ensemble of NLRP3PYD into a seed structure for ASC oligomerization. The introduction of the NLRP3 PYD-linker-FISNA sequence into NLRP6 resulted in a chimeric receptor able to be activated by K+ efflux-specific NLRP3 activators and promoted an in vivo inflammatory response to uric acid crystals. Our results establish that the N-terminal sequence between PYD and NACHT domain of NLRP3 is key for inflammasome activation.

Host: Dr. Miguel Segura Ginard, Senior researcher- Childhood Cancer and Blood Disorders (VHIR)

Register here to attend by Zoom: https://gencat.zoom.us/j/93529101286

Related activities

Curs SedUCI 2024. Per una estratègia protectora. De la teoria a la pràctica

06/03/2024 - 08:30
Professionals involucrats en la cura del pacient crític i amb interès a oferir el millor maneig de la sedació, analgèsia i delirium.
More information

III Jornada Parkinson Vall d’Hebron '40 anys tractant i investigant la malaltia de Parkinson'

06/06/2024 - 15:30
More information

Escuela de Verano de genética asistencial. Aplicación práctica de la genética en contexto clínico

06/10/2024 - 16:00
More information

3er Curs Patologia Hipotàlem Hipofisiària

06/11/2024 - 08:15
Professionals sanitaris
More information

Subscribe to our newsletters and be a part of Campus Life

Select the newsletter you want to receive:

By accepting these conditions, you are agreeing to the processing of your personal data for the provision of the services requested through this portal, and, if necessary, for any procedures required by the administrations or public bodies involved in this processing, and their subsequent inclusion in the aforementioned automated file. You may exercise your rights to access, rectification, cancellation or opposition by writing to web@vallhebron.cat, clearly stating the subject as "Exercising of Data Protection Rights".
Operated by: Hospital Universitari Vall d'Hebron - Institut Català de la Salut.
Purpose: Manage the user’s contact information.
Legitimisation: Express acceptance of the privacy policy.
Rights: To access, rectify, and delete personal information data, as well to the portability thereof and to limit and/or oppose their use.
Source: The interested party themselves.