Sjögren's Syndrome

Sjögren's Syndrome is a chronic, systemic autoimmune disease, the cause of which is unknown. Its main symptoms are a dry mouth (xerostomia) and dry eyes (xerophthalmia). In this disease, the cells making up our defence system (immune system) attack parts of the body itself, such as the glands that keep the eyes and mouth moist, and glands in other parts of the body, altering their function. Symptoms in other organs, such as the lungs, joints or nervous system, may also occur.

Authorship: Vall d'Hebron
Creation date: 04.04.2022, 13:37
Modification date: 04.04.2022, 13:38
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Musculoskeletal Techniques and Ultrasound Unit

The Musculoskeletal Techniques and Ultrasound Unit (MTU) at Vall d'Hebron Hospital Rheumatology Department is devoted to locomotive system ultrasound in all its forms (diagnostic/therapeutic) and other procedures and interventions and serves adult and paediatric patients.

Creation date: 04.04.2022, 13:25
Modification date: 04.04.2022, 15:17
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Juvenile onset systemic autoimmune diseases

Paediatric age onset systemic autoimmune diseases are infrequent, complex entities that require a multi-disciplinary approach. The most frequent include juvenile onset systemic lupus erythematosus, mixed connective tissue disease, juvenile onset Sjögren’s syndrome, juvenile dermatomyositis, juvenile scleroderma, and paediatric age onset vasculitis, such as Kawasaki disease, IgA vasculitis (also known as Schönlein-Henoch purpura), polyarthritis nodosa and Takayasu disease.

Authorship: Vall d'Hebron
Creation date: 04.04.2022, 13:19
Modification date: 04.04.2022, 13:19
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Inflammatory myopathies

Idiopathic inflammatory myopathies are a heterogeneous group of illnesses whose main feature is muscular weakness and identification of an underlying inflammation in the muscular biopsy. The group includes dermatomyositis, polymyositis and, recently, inclusion body myosotis, which is most probably the least inflammatory, as well being the myopathy most frequently acquired by the over 50s. Although the main target organ is muscle, the skin and lungs, amongst other internal organs, are frequently affected, for which reason inflammatory myopathies are considered to be systemic illnesses.

Authorship: Vall d'Hebron
Creation date: 04.04.2022, 09:58
Modification date: 04.04.2022, 09:59
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Paediatric Rheumatology Unit

The Paediatric Rheumatology Unit (PRU) at Vall d’Hebron University Hospital sits within the Rheumatology Department and is tasked with specialist care of locomotive system inflammatory disorders and other autoimmune diseases affecting paediatric patients. It consists of two rheumatology specialists with specific training in paediatric rheumatology disorders, Dr Estefanía Moreno Ruzafa and Dr Mireia López Corbeto, a specialist in Paediatrics with specific training in paediatric rheumatology, Dr Laia Martínez Mitjana, and a nurse specialising in rheumatic disorders in children, Julia Vivancos Pons.

Authorship: Mireia Lopez Corbeto
Creation date: 04.04.2022, 09:51
Modification date: 04.04.2022, 15:27
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Bone Metabolism Unit

The Bone Metabolism Unit (UMO) focuses on detecting, treating, and monitoring patients with metabolic bone disorders. Our specialized care comprises pathologies ranging from osteoporosis, which is the most common of these disorders, to Paget's disease and osteomalacia, and includes rare diseases like osteogenesis imperfecta.

Authorship: Maria Pascual Pastor
Creation date: 14.03.2022, 12:07
Modification date: 08.04.2022, 14:43
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Osteogenesis imperfecta

Osteogenesis imperfecta (OI), also known as "brittle bone disease", is a genetic disorder that affects the production of collagen, a principal element in connective tissue and bone. These individuals easily sustain fractures, even without trauma. There are various types of OI, so symptoms can vary. In most cases, the disease is caused by a mutation in the gene coding for type I collagen.

Authorship: Vall d'Hebron
Creation date: 14.03.2022, 10:06
Modification date: 14.03.2022, 10:07
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Osteomalacia and rickets

Osteomalacia is a skeletal mineralisation disorder. The bones are soft and this causes deformation and fractures, even without trauma, especially affecting the pelvis, ribs, and spinal column. In addition, it can cause pain, especially in the spinal column, pelvis, legs, and ribs, as well as weakness in the legs. In childhood, this disorder is called rickets and it can also negatively affect growth.

Authorship: Vall d'Hebron
Creation date: 14.03.2022, 09:37
Modification date: 14.03.2022, 09:39
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Paget's disease

This is the second most frequent bone disorder, following osteoporosis.  It affects 1.5-3% of the population over 65 years of age. It was described by Sir James Paget in 1876. In this disease, the natural process of the destruction of old bone and the formation of new bone (called bone remodelling) is abnormal and disordered. As a consequence, the bone is fragile, it increases in size, and it presents deformity. Thus, it also receives the name of deforming osteitis. It usually affects the cranium, spinal column, and the pelvis. The risk of having this disease increases with age, and it is very rare in young people.

Authorship: Vall d'Hebron
Creation date: 14.03.2022, 09:23
Modification date: 14.03.2022, 09:25
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Immune-mediated adverse effects related to cancer immunotherapy

Immunotherapy has revolutionised the treatment of some cancers in recent years. The immune system's job is to recognise and eliminate tumour cells, which prevents the appearance of tumours. However, when the tumour cells evade the immune system or it is not able to contain the tumour, that is when the cancer becomes apparent. The principle underlying immunotherapy is over-activating the immune system so that it can act against tumour cells. Nevertheless, this over-activation of the immune system can favour the appearance of inflammatory autoimmune diseases such as arthritis or myositis.

Creation date: 14.03.2022, 12:14
Modification date: 14.03.2022, 12:53
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