We are the combination of four hospitals: the General Hospital, the Children’s Hospital, the Women’s Hospital and the Traumatology, Rehabilitation and Burns Hospital. We are part of the Vall d’Hebron Barcelona Hospital Campus: a world-leading health park where healthcare plays a crucial role.
Patients are the centre and the core of our system. We are professionals committed to quality care and our organizational structure breaks down the traditional boundaries between departments and professional groups, with an exclusive model of knowledge areas.
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The commitment of Vall d'Hebron University Hospital to innovation allows us to be at the forefront of medicine, providing first class care adapted to the changing needs of each patient.
Speaker: Octavio Alfredo Romero Ferraro, principal investigator cancer epigenetics and Biology Program - Josep Carreras Research Institute (IJC)
In Pediatric cancer, the traditional cytotoxic therapeutic approaches are always a compromise between treatment efficacy and the risk of developing severe secondary effects, including new tumours during the adulthood. Our previous study demonstrates that SMARCA4 is necessary to regulate the demethylase activity of H3K27me3 in cancer, we discover that the inhibition of KDM6A/B is lethal specifically in SMARCA4 deficient tumors. This discovery implicates a new synthetic lethality, in which inactivating mutations in SWI/SNF members could sensitize cancer cells to specific epigenetic inhibitors affecting pediatric tumours.
Host: Miguel Segura Ginard, main researcher Childhood Cancer and Blood Disorders (VHIR)
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