Seminari de Recerca "Towards HBV cure : challenges and recent advances"

 Seminaris
  Sala d’actes de la planta baixa de l’Hospital General — See in map
15/11/2022
15/11/2022 -- From 15:00h to 16:00h
Organize :
Recerca Vall d'Hebron (VHIR)
Modality: Presencial i en línia
Share it:

Dr. Barbara Testoni, Barbara Testoni is a PI in the “Viral Hepatitis” team at CRCL – INSERM -Lyon

HBV is a small non-cytopathic DNA virus that is associated with a persistent infection in the majority of cases, giving rise to a series of complications that collectively represent a leading cause of death worldwide. In spite of universal vaccination programs, chronic HBV infection (CHB) affects more than 250 million people worldwide, which are at higher risk of developing liver cancer. Available therapeutic regimens require indefinite treatment to maintain viral suppression and prevent the virological relapse that usually occurs after treatment discontinuation, since therapies do not achieve elimination of the virus from the infected liver. Thus, CHB is an unmet medical need that requires a continuous effort to develop novel molecules, combination therapies and methods for their characterization in order to achieve the goal of HBV elimination. New in vitro and ex vivo models, as well as new clinical biomarkers are therefore needed to assist the development of new therapeutic strategies aiming at targeting the intrahepatic viral reservoir.

CV.: Barbara Testoni obtained her PhD in Genetics and Molecular Biology at the University of Milan in 2005, working on eukaryotic transcriptional regulation in the setting of skin development. Then, she moved to the University of Rome “La Sapienza”, where she began to work on liver disease and type-I interferon signaling. She particularly focused on the epigenetics mechanisms at the basis of Hepatitis C virus-driven Interferon stimulated genes (ISGs) deregulation in liver biopsies from HCV infected patients. At present, she is a PI in the “Viral Hepatitis” team at CRCL – INSERM U1052 in Lyon. Her research interests mainly include the investigation of the epigenetic mechanisms at the basis of host and viral gene regulation during HBV infection, with particular focus on the transcriptional regulation of the HBV minichromosome. She is also involved in translational studies, to the aim of understanding the relationships between HBV persistence and intrahepatic innate immunity perturbations and to characterizing new serum biomarkers for intrahepatic cccDNA activity. She is an active member of the International Coalition to Eliminate HBV (ICE-HBV) and member of the Emerging Scientific and Medical Advisory Board (eSMAB) of the Hepatitis B Foundation.

Host: Dr. Francesca Cortese, Microbiology (VHIR)

Online Connection:  https://gencat.zoom.us/j/98670640161

 

Related activities

Introducción a la hidrocefalia y alteraciones de la dinámica de LCR

09/02/2024 - 09:00
More information

XIX Curso teórico-práctico de Ecocardiografía básica y avanzada en medicina de urgencias, intensiva y anestesia

09/16/2024 - 09:00
Cardiología, Medicina Intensiva, Anestesia y Reanimación, Neurología
More information

Fundamentos fisiopatológicos de la hipoxia tisular y monitorización del aporte cerebral de oxígeno

09/30/2024 - 09:00
Facultativos especialistas, residentes y personal de enfermería interesados ​​en el manejo del paciente neurocrítico
More information

II Curso CARE ME

10/03/2024 - 08:45
Cardiología y Nefrología
More information

Subscribe to our newsletters and be a part of Campus Life

Select the newsletter you want to receive:

By accepting these conditions, you are agreeing to the processing of your personal data for the provision of the services requested through this portal, and, if necessary, for any procedures required by the administrations or public bodies involved in this processing, and their subsequent inclusion in the aforementioned automated file. You may exercise your rights to access, rectification, cancellation or opposition by writing to web@vallhebron.cat, clearly stating the subject as "Exercising of Data Protection Rights".
Operated by: Hospital Universitari Vall d'Hebron - Institut Català de la Salut.
Purpose: Manage the user’s contact information.
Legitimisation: Express acceptance of the privacy policy.
Rights: To access, rectify, and delete personal information data, as well to the portability thereof and to limit and/or oppose their use.
Source: The interested party themselves.